A hidden weapon that could help fight off the virus.
>Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals
Read much more from below excerpts at Source: >Some People May Have a Head Start Against Coronavirus, Surprising Evidence Shows
“Some people’s immune systems may have a head start in fighting the coronavirus, recent research suggested. A study published last month in the journal Cell showed that some people who have never been exposed to the coronavirus have helper T cells that are capable of recognizing and responding to it.
“The likeliest explanation for the surprising finding, according to the researchers, is a phenomenon called cross-reactivity: when helper T cells developed in response to another virus react to a similar but previously unknown pathogen. In this case, those T cells may be left over from people’s previous exposure to a different coronavirus – likely one of the four that cause common colds.
“The immune memory is related to the event. If it’s a strong event, you’ll have a strong memory, If you almost got run over by a truck, you’ll remember it, but you may not remember the color of the socks you wore yesterday because it’s not a big deal….it’d be interesting to study people with severe disease and compare the T-cell response between them and those with mild disease. That’s next on the docket, …”We’re looking to identify T-cell response in the critically hospitalized,” he said. “It’s being done as we speak.”
As more and more people get tested for antibodies to the coronavirus, infectious disease specialists worry that those tested — and their employers — may not understand the limits of the results.
>Google search on this topic, last month:
5 minute podcast and read full story at Source: >Antibody Testing Is Increasing, But A Positive Result Doesn’t Prove Immunity : Shots – Health News : NPR
“It’s still not certain that antibodies measured by such a test would protect him from catching the virus again. And if the antibodies are protective, it’s unknown how strong that protection might be or how long it might last. There are also questions about the reliability of many antibody tests being sold.
“Researchers are urgently trying to answer those uncertainties and figure how best to conduct antibody testing. Nevertheless, increasing numbers of people are getting the tests — many without recognizing how much is still unknown about what the results mean.
“the antibody tests are only a sign of past infection. Whether the infection is actually gone can only be determined by a diagnostic test that identifies genetic material from the virus or viral particles. Some people also falsely think testing positive on an antibody test proves they can’t get infected with the virus again.
Read full story at Source: >Antibody Testing Is Increasing, But A Positive Result Doesn’t Prove Immunity : Shots – Health News : NPR
>More NPR stories about this.
3 Minute Podcast and Full story of transcript below at Source: >What People Can Learn From The Discovery Of A Polio Vaccine : NPR
“People in the 1950s anxiously waited for scientists to come up with ways to protect children from polio. The road to a polio vaccine might contain some lessons for today’s health crisis. Most health experts say a vaccine will be needed to end the COVID-19 pandemic.
“It wouldn’t be the first time a vaccine ended a disease that terrorized Americans. In the 1950s, people waited anxiously for scientists to come up with a way to prevent children from coming down with infantile paralysis, better known as polio.
“NPR’s Joe Palca has the story of the bumpy road to a polio vaccine and the lessons it holds for today’s health crisis … Even former President Franklin D. Roosevelt had been stricken with it as a child. Then, as now, scientists felt a vaccine was the only way to end the epidemic…
“it was clear that Salk’s camp could produce the quicker vaccine…Millions of parents volunteered their children to be part of the March of Dimes’ trial of the vaccine…The trial took place in the spring of 1954, and the vaccine was approved for distribution a year later…The public health service immediately licensed five different pharmaceutical firms to produce it. And one of them did not do a good job…Mysteriously, some children develop symptoms of polio after receiving the vaccine.
“It turned out there was a problem with the vaccine made by Cutter Laboratories. The company’s manufacturing process did not fully kill the virus they used to make their vaccine. And as a result, hundreds of children who got the Cutter vaccine got polio, and some died. The debacle with the Cutter laboratory shattered public trust in the vaccine, though once the problem was identified and fixed, people started getting vaccinated again.
…the story of the Salk vaccine is one of the great success stories of American medical research… Through the largest public health experiment in American history, they produced this remarkable result, but that in the end, you know, Cutter also tells you, you got to be cautious. You know, you can’t do it too quickly.
(If we put on flat hats, can we go out then?)
11 Minute Podcast and full story at >Call For Public Health Investment
“NPR’s Steve Inskeep talks to Scott Gottlieb, ex-head of the FDA, and Andy Slavitt, who led the Centers for Medicare and Medicaid, about the letter they wrote to Congress with a plan to reopen the U.S.
“What will it take for Americans to get back to work? Two veteran voices in American health care are offering answers…
“…we’re going to have to have an aggressive system in place to try to identify positive cases through testing. And when we do find people who are infected with coronavirus, we have to have a system in place to allow them to self-isolate so that they don’t continue to spread infection. That’s going to require us to hire many more public health workers to do the contact tracing, basically the blocking and tackling of public health work, where you identify people, and then you go out and talk to them and then interview people who may have been in contact with them and offer them testing.
“What we’re going to be doing as we enter into the fall, in particular, as coronavirus starts to collide with flu season and we face the risk of large outbreaks and maybe another epidemic heading into the winter, what we’re going to be trying to do is get ahead of this and put in place enough layers of protection that you mitigate spread. We’re never going to be able to reduce all spread…
“We’re at a point right now where we’re seeing cases across the country plateau, but we still have 30,000 cases a day that we’re recording. There’s many more that we’re not capturing. We’re still having 2,000 deaths a day. So we’ve plateaued, but we haven’t really seen the sustained declines that we think we need in order to really safely start to restart economic activity. In fact, really, when you look at it, only about five states have shown sustained reductions in new cases that meet the criteria set out by the administration in terms of when you would contemplate restarting activity. So the best thing we can do to get consumers back and get the economy vibrant again is give people confidence that we’ve controlled this epidemic, the virus isn’t circulating widely and people’s risk of contracting it if they go out is low again.”
Posted in Communications, Education, Infections, Management, Tests
Tagged antibody, business, covid19, economy, Immunity, infection, isolation, pandemic, Symptoms, virus rate
(Video) “COVID-19 Update 54 with critical care specialist Roger Seheult, MD of https://www.MedCram.com Production of COVID-19 antibody test kits are ramping up – there are over 70 companies producing them. Antibody tests could be one of the keys to eventually easing social distancing restrictions and allowing schools and businesses to re-open. Unfortunately, only one antibody test is FDA approved at this time, and the approval of each company will take some time. Dr. Seheult illustrates how antibody tests and PCR-RT tests for COVID-19 work on the cellular level, and he discusses potential coronavirus vaccine challenges.”
“Stanford is testing for coronavirus antibodies so they can determine who has been exposed and who could potentially go back to school or work. NPR’s Lulu Garcia-Navarro speaks to Dr. Jay Bhattacharya.LULU GARCIA-NAVARRO,
“HOST:The only way we’ll truly get a hold of this pandemic and come out the other side is through science – ultimately with a vaccine, but in the meantime through testing. There are tests that determine if someone who is sick has COVID-19 by taking nasal swabs, but also important is something called antibody or serological tests. And one of the places that’s doing that is Stanford University. Joining us now is Dr. Jay Bhattacharya, professor of medicine at Stanford University, who is part of this study:
Listen to 5 minute podcast and read full interview at Source: >How Antibody Tests Can Inform Public Policies To Mitigate Coronavirus Pandemic : NPR
“(Reuters) – As the United States works overtime to screen thousands for the novel coronavirus, a new blood test offers the chance to find out who may have immunity – a potential game changer in the battle to contain infections and get the economy back on track. Several academic laboratories and medical companies are rushing to produce these blood tests, which can quickly identify disease-fighting antibodies in people who already have been infected but may have had mild symptoms or none at all.
“This is different from the current, sometimes hard-to-come-by diagnostic tests that draw on a nasal swab to confirm active infection. “Ultimately, this (antibody test) might help us figure out who can get the country back to normal,” Florian Krammer, a professor in vaccinology at Mount Sinai’s Icahn School of Medicine, told Reuters. “People who are immune could be the first people to go back to normal life and start everything up again.”
Keep reading at Source: >U.S. companies, labs rush to produce blood test for coronavirus immunity – Reuters